| Title | Bottom-Up Synthesized Glucan Materials: Opportunities from Applied Biocatalysis |
|---|---|
| ID_Doc | 13130 |
| Authors | Zhong, C; Nidetzky, B |
| Title | Bottom-Up Synthesized Glucan Materials: Opportunities from Applied Biocatalysis |
| Year | 2024 |
| Published | Advanced Materials, 36.0, 27 |
| Abstract | Linear d-glucans are natural polysaccharides of simple chemical structure. They are comprised of d-glucosyl units linked by a single type of glycosidic bond. Noncovalent interactions within, and between, the d-glucan chains give rise to a broad variety of macromolecular nanostructures that can assemble into crystalline-organized materials of tunable morphology. Structure design and functionalization of d-glucans for diverse material applications largely relies on top-down processing and chemical derivatization of naturally derived starting materials. The top-down approach encounters critical limitations in efficiency, selectivity, and flexibility. Bottom-up approaches of d-glucan synthesis offer different, and often more precise, ways of polymer structure control and provide means of functional diversification widely inaccessible to top-down routes of polysaccharide material processing. Here the natural and engineered enzymes (glycosyltransferases, glycoside hydrolases and phosphorylases, glycosynthases) for d-glucan polymerization are described and the use of applied biocatalysis for the bottom-up assembly of specific d-glucan structures is shown. Advanced material applications of the resulting polymeric products are further shown and their important role in the development of sustainable macromolecular materials in a bio-based circular economy is discussed. Linear d-glucans, simple yet versatile polysaccharides, shape nanostructures crucial for biomaterial development. Shifting from top-down to bottom-up synthesis using natural and engineered enzymes provides meticulous control over polymer structures, fostering diversification for macromolecular materials. This review introduces advancements in non-natural glucans, copolymers, and supramolecular hybrids, obtained through bottom-up enzymatic approaches. It emphasizes the potential of enzyme biocatalysis in material development. image |
| https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202400436 |
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