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Title From Microbial Succinic Acid Production to Polybutylene Bio-Succinate Synthesis
ID_Doc 17234
Authors Tenhaef, N; Hermann, A; Müeller, MF; Göertz, J; Marienhagen, J; Oldiges, M; Wiechert, W; Bott, M; Jupke, A; Hartmann, L; Herres-Pawlis, S; Noack, S
Title From Microbial Succinic Acid Production to Polybutylene Bio-Succinate Synthesis
Year 2023
Published Chemie Ingenieur Technik, 95, 4
Abstract A simplified and scalable one-pot process for the anaerobic production of succinic acid using a metabolically engineered Corynebacterium glutamicum strain is demonstrated. With targeted bioprocess optimization, succinic acid titer of 78 g L-1 and yield of 1.41 mol(SA)mol(GLC)(-1) were achieved. Succinic acid was recovered from the neutral fermentation broth by electrochemically induced crystallization and applied for polybutylene bio-succinate synthesis using a biocompatible zinc catalyst. Except for a slight color change, the final biopolymer was comparable to the polymer from commercial precursors.
PDF https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cite.202200163

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