| Title | Photochemical Vs Thermal Acid Catalysed Cyclization of Cannabigerol (CBG): An Unexpected Selectivity |
|---|---|
| ID_Doc | 19977 |
| Authors | Bini, A; Mella, M; Merli, D; Protti, S |
| Title | Photochemical Vs Thermal Acid Catalysed Cyclization of Cannabigerol (CBG): An Unexpected Selectivity |
| Year | 2024 |
| Published | |
| Abstract | The reactivity of Cannabigerol (CBG, 1) in organic solvents under photochemical and acid catalyzed conditions has been investigated in detail. The obtained results pointed out the presence of different reaction paths in the photochemical and the acid-catalyzed conditions, with a remarkable selectivity toward the formation of a 2,2-disubstituted-chromane derivative in the first case. The light driven selective cyclization of Cannabigerol (CBG), due to the photoacidity of the phenolic moieties present has been investigated in different organic solvents, and the results compared with those obtained by treating CBG with sulfonic acids, in order to point out the presence of different reaction mechanisms. image |
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