| Title | Crinum L. species as a potential source of alkaloids: Extraction methods and relevance for medicinal and pharmacological applications |
|---|---|
| ID_Doc | 24962 |
| Authors | de Araújo, RL; de Pinho, CLC; Farias, FO; Igarashi-Mafra, L; Mafra, MR |
| Title | Crinum L. species as a potential source of alkaloids: Extraction methods and relevance for medicinal and pharmacological applications |
| Year | 2022 |
| Published | |
| Abstract | The present review seeks to associate the bioactive profile, forms of extraction, and possible applications of the compounds present in non-endemic species of Crinum L. (Amaryllidaceae) found in Brazil. This genus is well-known for its isoquinoline alkaloids with variable biological activities and chemical structures. In this work, a bibliometric analysis was carried out with a literature review in the SCOPUS database to highlight and correlate research on the selected Crinum species: C. ornatum (Aiton) Herb., C. americanum L., C. x powellii hort. ex Baker, C. jagus (J.Thomps) Dandy., C. erubescens L.f. ex Aiton. To date, only 43 studies have been published on these species. These works reveal that these plants are rich mainly in alkaloids and other bioactive compounds, such as phenolic compounds, alcohols, fatty acids, etc. The alkaloids present in these plants are mainly responsible for their biological properties with cytotoxic, antibacterial, antifungal, and anti-diabetic potential, and as an acetylcholinesterase inhibitor. In addition, different solvents, extraction, and separation methods have been reported to obtain these biomolecules. The bioactives found in these plants can supply the search for compounds for applications in the medical and pharmaceutical industries, being, therefore, potential sources to be used in the promotion of human health. Thus, this review contributes to the valorization of these species and instigates new research in multidisciplinary areas. (c) 2022 SAAB. Published by Elsevier B.V. All rights reserved. |
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