| Title |
Circular economyeast: Saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application |
| ID_Doc |
8599 |
| Authors |
Sousa, P; Tavares-Valente, D; Pereira, CF; Pinto-Ribeiro, I; Azevedo-Silva, J; Madureira, R; Ramos, OL; Pintado, M; Fernandes, J; Amorim, M |
| Title |
Circular economyeast: Saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application |
| Year |
2024 |
| Published |
|
| Abstract |
Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water -insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from spent yeast in an industrial fermentation process and a wild strain produced through lab -scale fermentation. Two water -insoluble extracts with a high glucose content ( > 90 %) were achieved and further subjected to a chemical modification using carboxymethylation to improve their water solubility. All the glucans' extracts, water -insoluble and carboxymethylated, were structurally and chemically characterized, showing almost no differences between both yeast -type strains. To ensure their safety for skin application, a broad safety assessment was undertaken, and no cytotoxic effect, immunomodulatory capacity (IL -6 and IL -8 regulation), genotoxicity, skin sensitization, and impact on the skin microbiota were observed. These findings highlight the potential of glucans derived from spent yeast as a sustainable and safe ingredient for cosmetic and skincare formulations, contributing to the sustainability and circular economy. |
| PDF |
https://doi.org/10.1016/j.ijbiomac.2024.130933
|
