| Title | Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations |
|---|---|
| ID_Doc | 9656 |
| Authors | Gómez-Zorita, S; Milton-Laskibar, I; Eseberri, I; Beaumont, P; Courtois, A; Krisa, S; Portillo, MP |
| Title | Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations |
| Year | 2023 |
| Published | Nutrients, 15.0, 4 |
| Abstract | Viniferin is a phenolic compound belonging to the group of stilbenoids. In particular, epsilon-viniferin is a dimer of resveratrol, found in many plant genders, among which grapes (Vitis vinifera) are a primary source. Due to the fact that epsilon-viniferin is mainly present in the woody parts of plants, their use as a source of this bioactive compound is a very interesting issue in a circular economy. Both, in vitro studies carried out in pre-adipocytes and mature adipocytes and in vivo studies addressed in mice show that epsilon-viniferin is able to reduce fat accumulation. Moreover, it prevents the development of some obesity co-morbidities, such as type 2 diabetes, dyslipidemias, hypertension and fatty liver. epsilon-viniferin can be absorbed orally, but it shows a very low bioavailability. In this scenario, further research on animal models is needed to confirm the effects reported in a great number of studies; to determine which metabolites are involved, including the main one responsible for the biological effects observed and the mechanisms that justify these effects. In a further phase, human studies should be addressed in order to use epsilon-viniferin as a new tool for obesity management, as a nutraceutical or to be included in functional foods. |
| https://www.mdpi.com/2072-6643/15/4/928/pdf?version=1676205953 |
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