| Title |
Fabrication and characterization of porous pectin-based aerogels for drug delivery |
| ID_Doc |
10021 |
| Authors |
Suttiruengwong, S; Konthong, S; Pivsa-Art, S; Plukchaihan, P; Meesuwan, P; Wanthong, M; Panpradist, N; Kurien, RA; Pakawanit, P; Sriamornsak, P |
| Title |
Fabrication and characterization of porous pectin-based aerogels for drug delivery |
| Year |
2024 |
| Published |
|
| DOI |
10.1016/j.carpta.2024.100499 |
| Abstract |
Aerogels are renowned for their exceptional characteristics such as high porosity and ultra-low density. Among these, pectin aerogels, offering biodegradability, low toxicity, and versatility, are prominent candidates for innovative biomedical materials. This study focused on synthesizing pectin-based aerogels as carriers for ibuprofen and diclofenac sodium. Hydrogels were formed by combining a low methoxy pectin with calcium chloride solution, followed by dehydration and drying using either supercritical carbon dioxide (scCO2) or freeze-drying. Comparative analysis showed scCO2-dried aerogels exhibited slightly less shrinkage (0.27 %) than freeze-dried counterparts. Both types showed high porosity and mesoporous characteristics. However, scCO2dried aerogels demonstrated higher specific surface area, pore volume, and smaller pore diameter. FTIR spectra indicated no interaction between the drugs and pectin-based aerogels. The loading of ibuprofen in scCO2-dried, pectin-based aerogels at 90, 95, and 100 bar were 60.0 %, 59.9 %, and 52.1 %, respectively, and the solution loading of diclofenac sodium was 38.37 %. At 90, 95, and 100 bar, ibuprofen-loaded pectin-based aerogels were released at 90.0 %, 84.0 %, and 75.5 %, respectively. The release of diclofenac sodium-loaded, pectin-based aerogels was at 88.4 %. The Korsmeyer-Peppas model was fitted for both ibuprofen and diclofenac sodium, indicating the release is mainly driven by diffusion. |
| Author Keywords |
Hydrogels; Pectin; Aerogels; Supercritical fluid carbon dioxide; Specific surface area; Drug delivery |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Emerging Sources Citation Index (ESCI) |
| EID |
WOS:001235270000001 |
| WoS Category |
Chemistry, Applied; Polymer Science |
| Research Area |
Chemistry; Polymer Science |
| PDF |
https://doi.org/10.1016/j.carpta.2024.100499
|