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Scientific Article details

Title Survey of nonconventional yeasts for lipid and hydrocarbon biotechnology
ID_Doc 10447
Authors Rodriguez-Ocasio, E; Khalid, A; Truka, CJ; Blenner, MA; Jarboe, LR
Title Survey of nonconventional yeasts for lipid and hydrocarbon biotechnology
Year 2022
Published Journal Of Industrial Microbiology & Biotechnology, 49, 4
DOI 10.1093/jimb/kuac010
Abstract Nonconventional yeasts have an untapped potential to expand biotechnology and enable process development necessary for a circular economy. They are especially convenient for the field of lipid and hydrocarbon biotechnology because they offer faster growth than plants and easier scalability than microalgae and exhibit increased tolerance relative to some bacteria. The ability of industrial organisms to import and metabolically transform lipids and hydrocarbons is crucial in such applications. Here, we assessed the ability of 14 yeasts to utilize 18 model lipids and hydrocarbons from six functional groups and three carbon chain lengths. The studied strains covered 12 genera from nine families. Nine nonconventional yeasts performed better than Saccharomyces cerevisiae, the most common industrial yeast. Rhodotorula toruloides, Candida maltosa, Scheffersomyces stipitis, and Yarrowia lipolytica were observed to grow significantly better and on more types of lipids and lipid molecules than other strains. They were all able to utilize mid- to long-chain fatty acids, fatty alcohols, alkanes, alkenes, and dicarboxylic acids, including 28 previously unreported substrates across the four yeasts. Interestingly, a phylogenetic analysis showed a short evolutionary distance between the R. toruloides, C. maltosa, and S. stipitis, even though R. toruloides is classified under a different phylum. This work provides valuable insight into the lipid substrate range of nonconventional yeasts that can inform species selection decisions and viability of lipid feedstocks.
Author Keywords Hydrocarbon utilization; Substrate toxicity; Nonconventional yeast
Index Keywords Index Keywords
Document Type Other
Open Access Open Access
Source Science Citation Index Expanded (SCI-EXPANDED)
EID WOS:000804864800001
WoS Category Biotechnology & Applied Microbiology
Research Area Biotechnology & Applied Microbiology
PDF https://academic.oup.com/jimb/article-pdf/49/4/kuac010/45198254/kuac010.pdf
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