| Title |
Biodegradable polymer-based microfluidic membranes for sustainable point-of-care devices |
| ID_Doc |
12277 |
| Authors |
Brito-Pereira, R; Ribeiro, C; Lanceros-Méndez, S; Cardoso, VF |
| Title |
Biodegradable polymer-based microfluidic membranes for sustainable point-of-care devices |
| Year |
2022 |
| Published |
|
| DOI |
10.1016/j.cej.2022.137639 |
| Abstract |
Microfluidic paper-based analytical devices (mu PADs) have gained substantial attention as portable analytical devices in various (bio)technological fields, for being affordable, user-friendly, portable, energy efficient and for allowing multiplexed analysis. Although significant progress has been achieved, there is still need for improvement in terms of performance and sustainability. In this work, a biodegradable aliphatic polyester poly (D,L-lactide-co-glycolide acid) lactide:glycolide 50:50 (PDLG), is used to produce pore- and fibre-based membranes, as alternative to conventional paper substrates. Two fabrication methods are used, with potential for industrial scale-up. The processed hydrophobic membranes are post-treated with oxygen plasma to turn them hydrophilic, allowing capillary flows. The physicochemical characterization demonstrates the suitability of the plasma-treated PDLG membranes as microfluidic substrates based on their tailorable morphologies and capillary flow rate from 36.2 +/- 4.2 to 84.1 +/- 5.2 mm.min(-1), excellent mechanical properties and biocompatibility. Further, the membranes maintain their properties for at least 6 months when kept in vacuum and degrade quickly after their use (reaching values higher than 90 % after 6 weeks when wet). Finally, portable analytical platforms suitable for the colorimetric quantification of glucose are demonstrated. These results are of great importance for the design and manufacture of a new generation of sustainable portable analytical devices, compatible with circular economy paradigms, and a step forward to cross the challenging academia to industry barrier for their commercialization and widespread adoption. |
| Author Keywords |
Poly(lactide-co-glycolide acid); Biodegradable; Sustainability; Portable analytical devices; Point-of-care; Microfluidic |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000879314200002 |
| WoS Category |
Engineering, Environmental; Engineering, Chemical |
| Research Area |
Engineering |
| PDF |
https://doi.org/10.1016/j.cej.2022.137639
|