| Title |
Onion (Allium cepa L.) Skin Waste Valorization: Unveiling the Phenolic Profile and Biological Potential for the Creation of Bioactive Agents through Subcritical Water Extraction |
| ID_Doc |
12613 |
| Authors |
Trigueros, E; Benito-Román, O; Oliveira, AP; Videira, RA; Andrade, PB; Sanz, MT; Beltrán, S |
| Title |
Onion (Allium cepa L.) Skin Waste Valorization: Unveiling the Phenolic Profile and Biological Potential for the Creation of Bioactive Agents through Subcritical Water Extraction |
| Year |
2024 |
| Published |
Antioxidants, 13.0, 2 |
| DOI |
10.3390/antiox13020205 |
| Abstract |
Onion skin waste (OSW), the primary non-edible byproduct from onion processing, offers a renewable source of bioactive compounds. This study aims to valorize OSW through subcritical water extraction (SWE), aligning with a circular economy and biorefinery principles. SWE was carried out at 145 degree celsius and 50 bar for 50 min in a discontinuous reactor, producing a phenolic-rich extract (32.3 +/- 2.6 mg/g) dominated by protocatechuic acid (20.3 +/- 2.5 mg/g), quercetin-4'-O-glucoside (7.5 +/- 0.2 mg/g), and quercetin (3.2 +/- 0.6 mg/g). Additionally, the extract contains sugars (207.1 +/- 20.3 mg sucrose-Eq/g), proteins (22.8 +/- 1.6 mg BSA-Eq/g), and free amino acids (20.4 +/- 1.2 mg arginine-Eq/g). Its phenolic richness determines its scavenging activity against (NO)-N-center dot and O-2(center dot-) radicals and its alpha-glucosidase and aldose-reductase inhibition without affecting alpha-amylase. Notably, the extract demonstrates significant alpha-glucosidase inhibition (IC50 = 75.6 +/- 43.5 mu g/mL), surpassing acarbose (IC50 = 129.5 +/- 1.0 mu g/mL) in both pure enzyme and cell culture tests without showing cytotoxicity to AGS, HepG2, and Caco-2 human cell lines. The extract's bioactivity and nutritional content make it suitable for developing antioxidant and antidiabetic nutraceutical/food components, highlighting SWE's potential for OSW valorization without using organic solvents. |
| Author Keywords |
hydrothermal treatment; onion waste; polyphenols; quercetin; antioxidant activity; antidiabetic potential |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:001174974200001 |
| WoS Category |
Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology |
| Research Area |
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology |
| PDF |
https://www.mdpi.com/2076-3921/13/2/205/pdf?version=1707135881
|