| Title |
Supercritical CO2 extraction of bioactive lipids from canned sardine waste streams |
| ID_Doc |
17540 |
| Authors |
Rodrigues, LA; Pereira, CV; Partidário, AMC; Gouveia, LF; Simoes, P; Paiva, A; Matias, AA |
| Title |
Supercritical CO2 extraction of bioactive lipids from canned sardine waste streams |
| Year |
2021 |
| Published |
|
| DOI |
10.1016/j.jcou.2020.101359 |
| Abstract |
In this work supercritical carbon dioxide (sc-CO2) extraction was explored to recover bioactive lipids from canned sardine residues, with special focus on triglycerides. Aiming at enhancing the recovery of the target molecules, different extraction conditions were applied, including operating pressure (300-650 bar), temperature (35-80 degrees C) and CO2 flow rate (5-25 g/min). The performance of sc-CO2 extractions was compared with a conventional Bligh and Dyer extraction, and the resulting samples were characterized in terms of global yield and fatty acid profile. To evaluate their potential application as bioactive ingredients, extracts were screened for cytotoxicity, oxidative damage, and antiproliferative and anti-inflammatory activities in human intestinal cells (Caco-2 and HT-29). Our results showed that sc-CO2 extraction was able to produce extracts with anti-proliferative and anti-inflammatory properties, which can be potentially used as ingredients in different industrial health-related applications, namely dietary/nutritional supplements, or pharmaceutical products. |
| Author Keywords |
Canned sardine residues; Supercritical CO2 extraction; Bioactive fatty acids; Antiproliferative activity; Anti-inflammatory activity |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000606791300007 |
| WoS Category |
Chemistry, Multidisciplinary; Engineering, Chemical |
| Research Area |
Chemistry; Engineering |
| PDF |
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