| Title |
Investigation of Biological and Prooxidant Activity of Zinc Oxide Nanoclusters and Nanoparticles |
| ID_Doc |
19060 |
| Authors |
Ivanova, IA; Pavlova, EL; Kostadinova, AS; Toshkovska, RD; Yocheva, LD; El-Sayed, K; Hassan, MA; El-Zorkany, HE; Elshoky, HA |
| Title |
Investigation of Biological and Prooxidant Activity of Zinc Oxide Nanoclusters and Nanoparticles |
| Year |
2022 |
| Published |
Acta Chimica Slovenica, 69.0, 3 |
| DOI |
10.17344/acsi.2021.7337 |
| Abstract |
Zinc oxide (ZnO) nanomaterials offer some promising antibacterial effects. In this study, a new form of ZnO is synthesized, named ZnO nanocluster bars (NCs). Herein, ZnO NCs, ZnO nanoparticles (NPs), ZnO coated with silica (ZnO-SiOA, ZnO-SiOB), and SiO2 NPs were prepared, characterized, and their antimicrobial and prooxidant activity were tested. The prooxidant activity of all nanomaterials was studied according to free-radical oxidation reactions (pH 7.4 and pH 8.5) in chemiluminescent model systems. Each form of new synthesized ZnO nanomaterials exhibited a unique behavior that varied from mild to strong prooxidant properties in the Fenton's system. ZnO NPs and ZnO NCs showed strong antibacterial effects, ZnO-SiOA NPs did not show any antibacterial activity representing biocompatibility. All tested NMs also underwent oxidation by H2O2. ZnO NCs and ZnO NPs exhibited strong oxidation at pH 8.5 in the O-2(-center dot) generating system. While, SiO2, ZnO-SiOA and ZnO-SiOB possessed pronounced 60-80% antioxidant effects, SiO2 NPs acted as a definitive prooxidant which was not observed in other tests. ZnO NCs are strongly oxidized, assuming that ZnO NCs provide a slower release of ZnO, which leads to having a stronger effect on bacterial strains. Thus, ZnO NCs are an important antibacterial agent that could be an emergent replacement of traditional antibiotics. |
| Author Keywords |
ZnO; nanoclusters; nanocomposites; antimicrobial activity; ROS; chemiluminescence |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000883417200022 |
| WoS Category |
Chemistry, Multidisciplinary |
| Research Area |
Chemistry |
| PDF |
https://journals.matheo.si/index.php/ACSi/article/download/7337/3532
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