| Title |
A Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healing |
| ID_Doc |
20485 |
| Authors |
Ferreira, CAM; Félix, R; Félix, C; Januário, AP; Alves, N; Novais, SC; Dias, JR; Lemos, MFL |
| Title |
A Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healing |
| Year |
2021 |
| Published |
Biomolecules, 11, 3 |
| DOI |
10.3390/biom11030461 |
| Abstract |
Brown seaweeds are recognized sources of compounds with a wide range of properties and applications. Within these compounds, phlorotannins are known to possess several bioactivities (e.g., antioxidant, anti-inflammatory, and antimicrobial) with potential to improve wound healing. To obtain phlorotannins enriched extracts from Undaria pinnatifida, a biorefinery was set using low-cost industry-friendly methodologies, such as sequential solid-liquid extraction and liquid-liquid extraction. The obtained extracts were screened for their antioxidant and antimicrobial activity against five common wound pathogens and for their anti-inflammatory potential. The ethanolic wash fraction (wE100) had the highest antioxidant activity (114.61 +/- 10.04 mmol.mg(-1) extract by Diphenyl-1-picrylhydrazyl (DPPH) and 6.56 +/- 1.13 mM eq. Fe II.mg(-1) extract by and Ferric Reducing Antioxidant Power (FRAP)), acting efficiently against Gram-negative (Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, and showing a nitric oxide production inhibition over 47% when used at 0.01 mu g center dot mL(-1). NMR and FTIR chemical characterization suggested that phlorotannins are present. Obtained fraction wE100 proved to be a promising candidate for further inclusion as wound healing agents, while the remaining fractions analyzed are potential sources for other biotechnological applications, giving emphasis to a biorefinery and circular economy framework to add value to this seaweed and the industry. |
| Author Keywords |
anti-inflammatory; antimicrobial; antioxidant; circular economy; phlorotannins |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000633396900001 |
| WoS Category |
Biochemistry & Molecular Biology |
| Research Area |
Biochemistry & Molecular Biology |
| PDF |
https://www.mdpi.com/2218-273X/11/3/461/pdf?version=1616150611
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