| Title |
A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies |
| ID_Doc |
22748 |
| Authors |
Ferron, L; Colombo, R; Mannucci, B; Papetti, A |
| Title |
A New Italian Purple Corn Variety (Moradyn) Byproduct Extract: Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies |
| Year |
2020 |
| Published |
Molecules, 25.0, 8 |
| DOI |
10.3390/molecules25081958 |
| Abstract |
The reuse of byproducts from agricultural and food industries represents the key factor in a circular economy, whose interest has grown in the last two decades. Thus, the extraction of bioactives from agro-industrial byproducts is a potential source of valuable molecules. The aim of this work was to investigate the in vitro capacity of byproducts from a new Italian corn variety, named Moradyn, to inhibit the accumulation of advanced glycation end products (AGEs) involved in several chronic age-related disorders. In addition, the hypoglycemic effect of Moradyn was tested by in vitro enzymatic systems. A Moradyn phytocomplex and its purified anthocyanin fraction were able to inhibit fructosamine formation and exhibited antiglycative properties when tested using BSA-sugars and BSA-methylglyoxal assays. These properties could be attributed to the polyphenols, mainly anthocyanins and flavonols, detected by RP-HPLC-DAD-ESI-MSn. Finally, a Moradyn phytocomplex was submitted to a simulated in vitro digestion process to study its bioaccessibility. Moradyn could be considered as a promising food ingredient in the context of typical type 2 diabetes risk factors and the study will continue in the optimization of the ideal formulation to preserve its bioactivities from digestion. |
| Author Keywords |
Zea mays L.; purple corn byproduct; circular economy; polyphenols; anthocyanins; antiglycative capacity; advanced glycation end products; hypoglycemic effect; in vitro simulated digestion process |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000534617300113 |
| WoS Category |
Biochemistry & Molecular Biology; Chemistry, Multidisciplinary |
| Research Area |
Biochemistry & Molecular Biology; Chemistry |
| PDF |
https://www.mdpi.com/1420-3049/25/8/1958/pdf
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