| Title |
Building a circular economy around poly(D/L-γ-glutamic acid)- a smart microbial biopolymer |
| ID_Doc |
28991 |
| Authors |
Parati, M; Khalil, I; Tchuenbou-Magaia, F; Adamus, G; Mendrek, B; Hill, R; Radecka, I |
| Title |
Building a circular economy around poly(D/L-γ-glutamic acid)- a smart microbial biopolymer |
| Year |
2022 |
| Published |
|
| DOI |
10.1016/j.biotechadv.2022.108049 |
| Abstract |
Bio-derived materials have long been harnessed for their potential as backbones of biodegradable constructs. With increasing understanding of organismal biochemistry and molecular genetics, scientists are now able to obtain biomaterials with properties comparable to those achieved by the petroleum industry. Poly-gamma-glutamic acid (gamma-PGA) is an anionic pseudopolypeptide produced and secreted by several microorganisms, especially Bacillus species. gamma-PGA is polymerised via the pgs intermembrane enzymatic complex expressed by many bacteria (including GRAS member -Bacillus subtilis). gamma-PGA can exist as a homopolymer of L-glutamic acid or D-glutamic acid units or it can be a co-polymer comprised of D and L enantiomers. This non-toxic polymer is highly viscous, soluble, biodegradable and biocompatible. gamma-PGA is also an example of versatile chiral-polymer, a characteristic that draws great attention from the industry. Increased understanding in the correlation between microbial genetics, substrate compositions, fermentation conditions and polymeric chemical characteristics have led to bioprocess optimisation to provide cost competitive, non-petroleum-based, biodegradable solutions. This review presents detailed insights into microbial synthesis of gamma-PGA and summaries current understanding of the cor-relation between genetic makeup of gamma-PGA-producing bacteria, range of culture cultivation conditions, and physicochemical properties of this incredibly versatile biopolymer. Additionally, we hope that review provides an updated overview of findings relevant to sustainable and cost-effective biosynthesis of gamma-PGA, with application in medicine, pharmacy, cosmetics, food, agriculture and for bioremediation. |
| Author Keywords |
Process optimisation; Biotechnology; Protein up scaling; Biomaterial; Circular economy; Waste valorisation; Versatile platform material; Biochemistry; Biosynthesis; Industrial biotechnology |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000878633900001 |
| WoS Category |
Biotechnology & Applied Microbiology |
| Research Area |
Biotechnology & Applied Microbiology |
| PDF |
https://doi.org/10.1016/j.biotechadv.2022.108049
|