| Title |
A green and cost-effective approach for the efficient conversion of grape byproducts into innovative delivery systems tailored to ensure intestinal protection and gut microbiota fortification |
| ID_Doc |
29845 |
| Authors |
Perra, M; Manca, ML; Tuberoso, CIG; Caddeo, C; Marongiu, F; Peris, JE; Orru, G; Ibba, A; Fernandez-Busquets, X; Fattouch, S; Bacchetta, G; Manconi, M |
| Title |
A green and cost-effective approach for the efficient conversion of grape byproducts into innovative delivery systems tailored to ensure intestinal protection and gut microbiota fortification |
| Year |
2022 |
| Published |
|
| DOI |
10.1016/j.ifset.2022.103103 |
| Abstract |
According to circular economy, wine-making by-products represent a fascinating biomass, which can be used for the sustainable exploitation of polyphenols and the development of new nanotechnological health-promoting products. In this study, polyphenols contained in the grape pomace were extracted by maceration with ethanol in an easy and low dissipative way. The obtained extract, rich in malvidin-3-glucoside, quercetin, pro-cyanidin B2 and gallic acid, was incorporated into phospholipid vesicles tailored for intestinal delivery. To improve their performances, vesicles were enriched with gelatine or a maltodextrin (Nutriose (R)), or their com-bination (gelatine-liposomes, nutriosomes and gelatine-nutriosomes). The small (-147 nm) and negatively charged (--50mV) vesicles were stable at different pH values mimicking saliva (6.75), gastric (1.20) and intestinal (7.00) environments. Vesicles effectively protected intestinal cells (Caco-2) from the oxidative stress and promoted the biofilm formation by probiotic bacteria. A preliminary evaluation of the vesicle feasibility at industrial levels was also performed, analysing the economic and energetic costs needed for their production. |
| Author Keywords |
Grape pomace extract; Phospholipid vesicles; Caco-2 cells; Probiotic bacteria; Manufacturing costs; Antioxidant activity |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000844033700008 |
| WoS Category |
Food Science & Technology |
| Research Area |
Food Science & Technology |
| PDF |
https://diposit.ub.edu/dspace/bitstream/2445/197285/1/2022_IFSET_AGreen_Perra_postprint.pdf
|