| Title |
Mixture Risk Assessment of Complex Real-Life Mixtures-The PANORAMIX Project |
| ID_Doc |
63413 |
| Authors |
Escher, BI; Lamoree, M; Antignac, JP; Scholze, M; Herzler, M; Hamers, T; Jensen, TK; Audebert, M; Busquet, F; Maier, D; Oelgeschläger, M; Valente, MJ; Boye, H; Schmeisser, S; Dervilly, G; Piumatti, M; Motteau, S; König, M; Renko, K; Margalef, M; Cariou, R; Ma, YY; Treschow, AF; Kortenkamp, A; Vinggaard, AM |
| Title |
Mixture Risk Assessment of Complex Real-Life Mixtures-The PANORAMIX Project |
| Year |
2022 |
| Published |
International Journal Of Environmental Research And Public Health, 19, 20 |
| DOI |
10.3390/ijerph192012990 |
| Abstract |
Humans are involuntarily exposed to hundreds of chemicals that either contaminate our environment and food or are added intentionally to our daily products. These complex mixtures of chemicals may pose a risk to human health. One of the goals of the European Union's Green Deal and zero-pollution ambition for a toxic-free environment is to tackle the existent gaps in chemical mixture risk assessment by providing scientific grounds that support the implementation of adequate regulatory measures within the EU. We suggest dealing with this challenge by: (1) characterising 'real-life' chemical mixtures and determining to what extent they are transferred from the environment to humans via food and water, and from the mother to the foetus; (2) establishing a high-throughput whole-mixture-based in vitro strategy for screening of real-life complex mixtures of organic chemicals extracted from humans using integrated chemical profiling (suspect screening) together with effect-directed analysis; (3) evaluating which human blood levels of chemical mixtures might be of concern for children's development; and (4) developing a web-based, ready-to-use interface that integrates hazard and exposure data to enable component-based mixture risk estimation. These concepts form the basis of the Green Deal project PANORAMIX, whose ultimate goal is to progress mixture risk assessment of chemicals. |
| Author Keywords |
mixture risk assessment; real-life mixtures; developmental neurotoxicity; reproductive toxicity; new methodological approaches; effect-directed analysis; effect-based trigger values; PANORAMIX |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) |
| EID |
WOS:000873134000001 |
| WoS Category |
Environmental Sciences; Public, Environmental & Occupational Health |
| Research Area |
Environmental Sciences & Ecology; Public, Environmental & Occupational Health |
| PDF |
https://www.mdpi.com/1660-4601/19/20/12990/pdf?version=1665480164
|