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Title Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates
ID_Doc 7955
Authors Russo, V; Continella, A; Drago, C; Gentile, A; La Malfa, S; Leotta, CG; Pulvirenti, L; Ruberto, G; Pitari, GM; Siracusa, L
Title Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates
Year 2021
Published Plos One, 16, 8
DOI 10.1371/journal.pone.0255831
Abstract Immature fruits from Punica granatum L. thinning are a neglected side product of pomegranate production with cumbersome disposal costs for farmers. To explore value potential of immature fruits from pomegranate 'Wonderful' cultivars, the compositional landscapes and antitumorigenic activities of pomegranate extracts from two different stages of maturation were assessed. Cancer cell proliferation and cytotoxicity was quantified in human lung H1299 and colon HCT116 adenocarcinomas by crystal violet staining, MTS assay and caspase-3 activity. High performance liquid chromatography-diode array detector (HPLC/DAD) and high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC/ESI-MS) analyses indicate that immature fruits are rich sources of gallotannins and ellagitannins, with the highest amounts contained in immature fruit peels. Biological investigations reveal a robust anticancer activity by those immature P. granatum fruit extracts, which reflected induction of tumor cytotoxicity and cell death mechanisms. Together, present observations suggest P. granatum byproducts from the thinning process may provide unexplored values for virtuous circular economy.
Author Keywords
Index Keywords Index Keywords
Document Type Other
Open Access Open Access
Source Science Citation Index Expanded (SCI-EXPANDED)
EID WOS:000683572000015
WoS Category Multidisciplinary Sciences
Research Area Science & Technology - Other Topics
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