| Title |
Valorization of Cheese Whey as a Feedstock for Production of Cyclosporin A by Tolypocladium inflatum |
| ID_Doc |
7983 |
| Authors |
Kim, HR; Lee, KH; Chun, Y; Lee, SK; Lee, JH; Kim, SW; Yoo, HY |
| Title |
Valorization of Cheese Whey as a Feedstock for Production of Cyclosporin A by Tolypocladium inflatum |
| Year |
2022 |
| Published |
Fermentation-Basel, 8, 12 |
| DOI |
10.3390/fermentation8120670 |
| Abstract |
Food waste-based biorefineries are considered an essential concept for the implementation of a sustainable circular economy. In this study, cheese whey powder (CWP), a dairy industry waste, was utilized to produce cyclosporin A (CsA). As it is difficult to valorize CWP because its components vary depending on the origin, a process for sugar conversion via acid hydrolysis was designed to obtain reproducible results using refined whey powder (WP) of a consistent quality. Acid hydrolysis was carried out using 2% (w/w) HCl and biomass loading of 50 g/L at 121 degrees C for 20 min. CWP hydrolysates were utilized to ferment Tolypocladium inflatum ATCC 34921. CsA production was found to be 51.3 mg/L at 12 days, a 1.4-fold increase compared to the control (commercial glucose, 36.3 mg/L). Our results showed that 100 g CWP can be converted to 81.8 mg of CsA. This finding demonstrated that CWP can be used as a sustainable feedstock for biorefineries. |
| Author Keywords |
biorefinery; food waste; cheese whey; acid hydrolysis; fermentation; Cyclosporin A |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000900860600001 |
| WoS Category |
Biotechnology & Applied Microbiology; Food Science & Technology |
| Research Area |
Biotechnology & Applied Microbiology; Food Science & Technology |
| PDF |
https://www.mdpi.com/2311-5637/8/12/670/pdf?version=1669253837
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