| Title |
Plastic Eating Enzymes: A Step Towards Sustainability |
| ID_Doc |
8160 |
| Authors |
Patel, SKS; Lee, JK |
| Title |
Plastic Eating Enzymes: A Step Towards Sustainability |
| Year |
2022 |
| Published |
Indian Journal Of Microbiology, 62.0, 4 |
| DOI |
10.1007/s12088-022-01041-w |
| Abstract |
The large-scale usage of petro-chemical-based plastics has proved to be a significant source of environmental pollution due to their non-biodegradable nature. Microbes-based enzymes such as esterases, cutinases, and lipases have shown the ability to degrade synthetic plastic. However, the degradation of plastics by enzymes is primarily limited by the unavailability of a robust enzymatic system, i.e., low activity and stability towards plastic degradation. Recently, the machine learning strategy involved structure-based and deep neural networks show desirable potential to generate functional, active stable, and tolerant polyethylene terephthalate (PET) degrading enzyme (FAST-PETase). FAST-PETase showed the highest PET hydrolytic activity among known enzymes or their variants and degraded broad ranges of plastics. The development of a closed-loop circular economy-based system of plastic degradation to monomers by FAST-PETase followed by the re-polymerization of monomers into clean plastics can be a more sustainable approach. As an alternative to synthetic plastics, diverse microbes can produce polyhydroxyalkanoates, and their degradation by microbes has been well-established. This article discusses recent updates in the enzymatic degradation of plastics for sustainable development. |
| Author Keywords |
Bio-degradation process; Machine learning strategy; Plastic degrading enzyme; Polyhydroxyalkanoates; Synthetic plastic |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000859762900001 |
| WoS Category |
Biotechnology & Applied Microbiology; Microbiology |
| Research Area |
Biotechnology & Applied Microbiology; Microbiology |
| PDF |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705608
|