| Title | Microbial conversion of carbon dioxide and hydrogen into the fine chemicals hydroxyectoine and ectoine |
|---|---|
| ID_Doc | 24520 |
| Authors | Cantera, S; Di Benedetto, F; Tumulero, B; Sousa, DZ |
| Title | Microbial conversion of carbon dioxide and hydrogen into the fine chemicals hydroxyectoine and ectoine |
| Year | 2023 |
| Published | |
| Abstract | This study explores a novel conversion of CO2 into the chemicals hydroxyectoine and ectoine, which are com-pounds with high retail values in the pharmaceutical industry. Firstly, 11 species of microbes able to use CO2 and H-2 and that have the genes for ectoines synthesis (ectABCD) were identified through literature search and genomic mining. Laboratory tests were then conducted to ascertain the capacity of these microbes to produce ectoines from CO2. Results showed that the most promising bacteria for CO2 to ectoines bioconversion are Hy-drogenovibrio marinus, Rhodococcus opacus, and Hydrogenibacillus schlegelii. Upon salinity and H-2/CO2/O-2 ratio optimization, H. marinus accumulated 85 mg of ectoine g biomass(-1). Interestingly, R. opacus and H. schlegelii mainly produced hydroxyectoine (53 and 62 mg g biomass(-1)), which has a higher commercial value. Overall, these results constitute the first proof of a novel valorization platform of CO2 and lay the foundation for a new economic niche aimed at CO2 recircularization into pharmaceuticals. |
| https://doi.org/10.1016/j.biortech.2023.128753 |
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