Knowledge Agora

Title	Consolidated microbial production of four-, five-, and six-carbon organic acids from crop residues: Current status and perspectives
ID_Doc	7491
Authors	Son, J; Joo, JC; Baritugo, KA; Jeong, S; Lee, JY; Lim, HJ; Lim, SH; Yoo, JI; Park, SJ
Title	Consolidated microbial production of four-, five-, and six-carbon organic acids from crop residues: Current status and perspectives
Year	2022
Published
Abstract	The production of platform organic acids has been heavily dependent on petroleum-based industries. However, petrochemical-based industries that cannot guarantee a virtuous cycle of carbons released during various processes are now facing obsolescence because of the depletion of finite fossil fuel reserves and associated environmental pollutions. Thus, the transition into a circular economy in terms of the carbon footprint has been evaluated with the development of efficient microbial cell factories using renewable feedstocks. Herein, the recent progress on bio-based production of organic acids with four-, five-, and six-carbon backbones, including butyric acid and 3-hydroxybutyric acid (C4), 5-aminolevulinic acid and citramalic acid (C5), and hexanoic acid (C6), is discussed. Then, the current research on the production of C4-C6 organic acids is illustrated to suggest future directions for developing crop-residue based consolidated bioprocessing of C4-C6 organic acids using host strains with tailor-made capabilities.
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