| Title | Upcycling CO2 into energy-rich long-chain compounds via electrochemical and metabolic engineering |
|---|---|
| ID_Doc | 7721 |
| Authors | Zheng, TT; Zhang, ML; Wu, LH; Guo, SY; Liu, XJ; Zhao, JK; Xue, WQ; Li, JW; Liu, CX; Li, X; Jiang, Q; Bao, J; Zeng, J; Yu, T; Xia, C |
| Title | Upcycling CO2 into energy-rich long-chain compounds via electrochemical and metabolic engineering |
| Year | 2022 |
| Published | Nature Catalysis, 5, 5 |
| Abstract | Upcycling of carbon dioxide (CO2) into value-added products represents a substantially untapped opportunity to tackle environmental issues and achieve a circular economy. Compared with easily available C-1/C-2 products, nevertheless, efficient and sustainable synthesis of energy-rich long-chain compounds from CO2 still remains a grand challenge. Here we describe a hybrid electro-biosystem, coupling spatially separate CO2 electrolysis with yeast fermentation, that efficiently converts CO2 to glucose with a high yield. We employ a nanostructured copper catalyst that can stably catalyse pure acetic acid production with a solid-electrolyte reactor. We then genetically engineer Saccharomyces cerevisiae to produce glucose in vitro from electrogenerated acetic acid by deleting all defined hexokinase genes and overexpression of heterologous glucose-1-phosphatase. In addition, we showcase that the proposed platform can be easily extended to produce other products like fatty acids using CO2 as the carbon source. These results illuminate the tantalizing possibility of a renewable-electricity-driven manufacturing industry. |
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