| Title |
Bottom-Up Synthesized Glucan Materials: Opportunities from Applied Biocatalysis |
| ID_Doc |
13130 |
| Authors |
Zhong, C; Nidetzky, B |
| Title |
Bottom-Up Synthesized Glucan Materials: Opportunities from Applied Biocatalysis |
| Year |
2024 |
| Published |
Advanced Materials, 36.0, 27 |
| DOI |
10.1002/adma.202400436 |
| Abstract |
Linear d-glucans are natural polysaccharides of simple chemical structure. They are comprised of d-glucosyl units linked by a single type of glycosidic bond. Noncovalent interactions within, and between, the d-glucan chains give rise to a broad variety of macromolecular nanostructures that can assemble into crystalline-organized materials of tunable morphology. Structure design and functionalization of d-glucans for diverse material applications largely relies on top-down processing and chemical derivatization of naturally derived starting materials. The top-down approach encounters critical limitations in efficiency, selectivity, and flexibility. Bottom-up approaches of d-glucan synthesis offer different, and often more precise, ways of polymer structure control and provide means of functional diversification widely inaccessible to top-down routes of polysaccharide material processing. Here the natural and engineered enzymes (glycosyltransferases, glycoside hydrolases and phosphorylases, glycosynthases) for d-glucan polymerization are described and the use of applied biocatalysis for the bottom-up assembly of specific d-glucan structures is shown. Advanced material applications of the resulting polymeric products are further shown and their important role in the development of sustainable macromolecular materials in a bio-based circular economy is discussed. Linear d-glucans, simple yet versatile polysaccharides, shape nanostructures crucial for biomaterial development. Shifting from top-down to bottom-up synthesis using natural and engineered enzymes provides meticulous control over polymer structures, fostering diversification for macromolecular materials. This review introduces advancements in non-natural glucans, copolymers, and supramolecular hybrids, obtained through bottom-up enzymatic approaches. It emphasizes the potential of enzyme biocatalysis in material development. image |
| Author Keywords |
bottom-up synthesis; carbohydrate-active enzymes; enzyme and material bioengineering; hybrid biomaterials; oligo-/polysaccharide materials |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:001198148700001 |
| WoS Category |
Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter |
| Research Area |
Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| PDF |
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202400436
|