| Title |
Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations |
| ID_Doc |
9656 |
| Authors |
Gómez-Zorita, S; Milton-Laskibar, I; Eseberri, I; Beaumont, P; Courtois, A; Krisa, S; Portillo, MP |
| Title |
Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations |
| Year |
2023 |
| Published |
Nutrients, 15.0, 4 |
| DOI |
10.3390/nu15040928 |
| Abstract |
Viniferin is a phenolic compound belonging to the group of stilbenoids. In particular, epsilon-viniferin is a dimer of resveratrol, found in many plant genders, among which grapes (Vitis vinifera) are a primary source. Due to the fact that epsilon-viniferin is mainly present in the woody parts of plants, their use as a source of this bioactive compound is a very interesting issue in a circular economy. Both, in vitro studies carried out in pre-adipocytes and mature adipocytes and in vivo studies addressed in mice show that epsilon-viniferin is able to reduce fat accumulation. Moreover, it prevents the development of some obesity co-morbidities, such as type 2 diabetes, dyslipidemias, hypertension and fatty liver. epsilon-viniferin can be absorbed orally, but it shows a very low bioavailability. In this scenario, further research on animal models is needed to confirm the effects reported in a great number of studies; to determine which metabolites are involved, including the main one responsible for the biological effects observed and the mechanisms that justify these effects. In a further phase, human studies should be addressed in order to use epsilon-viniferin as a new tool for obesity management, as a nutraceutical or to be included in functional foods. |
| Author Keywords |
viniferin; obesity; glucose homeostasis; dyslipidemia; hypertension; fatty liver |
| Index Keywords |
Index Keywords |
| Document Type |
Other |
| Open Access |
Open Access |
| Source |
Science Citation Index Expanded (SCI-EXPANDED) |
| EID |
WOS:000941028000001 |
| WoS Category |
Nutrition & Dietetics |
| Research Area |
Nutrition & Dietetics |
| PDF |
https://www.mdpi.com/2072-6643/15/4/928/pdf?version=1676205953
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